Elution Profiles of Synthetic CaSO4 Hemihydrate Beads Loaded with Vancomycin and Tobramycin
نویسندگان
چکیده
منابع مشابه
Fabrication and Structural, Mechanical, and Biological Characterization of Vancomycin-Loaded Chitosan-Hydroxyapatite-Gelatin Beads for Local Treatment of Osteomyelitis
Background and purpose: Topical antibiotic medication is an alternative method in treatment of local infections, especially osteomyelitis. Currently several biomaterials are used for this purpose. The present study focused on the fabrication and characterization of chitosan and Vancomycin (VCM)-loaded chitosan (CS)-hydroxyapatite (HA)-gelatin (G) bead in treatment of osteomyelitis. Materials ...
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BACKGROUND AND PURPOSE Late infections after total hip arthroplasty are still a problem. Treatment procedures include resection arthroplasty with implantation of antibiotic-loaded beads or implantation of an antibiotic-impreganted spacer. However, little is known about antibiotic elution from bone cement beyond the first 2-3 postoperative days in humans. METHODS 17 hip spacers (80 g PMMA, 1g ...
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The in vitro release of vancomycin, teicoplanin, gentamicin and clindamycin from biodegradable calcium sulphate (CaSO(4)) carrier beads is described. All antibiotics showed prolonged release from the carrier beads, which was elevated during the first 24 h, with peak levels exceeding 2500 microg/bead. Doubling the antibiotic load of the beads revealed a more prolonged elution and a two-fold incr...
متن کاملOptimized elution of daptomycin from polymethylmethacrylate beads.
We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin and gentamicin.
متن کاملIncreasing the elution of vancomycin from high-dose antibiotic-loaded bone cement: a novel preparation technique.
BACKGROUND Antibiotic bone cement is commonly used in staged revision arthroplasty as well as the treatment of open fractures. Multiple factors affect antibiotic elution from bone cement. This study was performed to investigate the effect of two variables, the quantity of liquid monomer and the timing of antibiotic addition, on the ultimate elution of antibiotic from bone cement. METHODS Vanc...
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ژورنال
عنوان ژورنال: European Journal of Drug Metabolism and Pharmacokinetics
سال: 2020
ISSN: 0378-7966,2107-0180
DOI: 10.1007/s13318-020-00622-8